Drug Discovery Engine to improve neuronal health
Clearance of toxic cellular components, whether they are damaged organelles, aggregated proteins, or accumulated lipids, is a fundamental function required for cell health. Mutations that impair clearance pathways are associated with the cause of multiple neurodegenerative diseases, including those with cognitive dysfunction. Caraway’s targeted approaches combine genetic data and unique biological understanding to discover small molecules that activate neurons’ clean-up and recycling processes thereby accelerating clearance of toxic materials and defective cellular components.